We, therefore, also analyzed the expression of β-catenin in MEN1-KD PCa cells, and found that MEN1 silencing resulted in the accumulation of β-catenin in the nucleus of DU145 and PC3 cells, with its membrane and cytoplasmic expression being markedly reduced (Fig. 4a-b and Fig. S4a). The gene discussed is MEN1; the disease is posterior cortical atrophy.