Recently, we demonstrated the decisive role played by the menin protein, encoded by the MEN1 gene, in regulating AR transcription in AR-dependent PCa cell lines [23]. Our findings also highlighted disparities in the effects of this protein on the proliferation of PCa cells, since MEN1 silencing had no impact (PC3 cells), or even an increased (DU145 cells) proliferation of AR-independent cells, whereas it led to a marked decrease in cell growth of AR-dependent lines (LNCaP, 22Rv1 and VCaP). This evidence concerns the gene AR and posterior cortical atrophy.