MEN1 and posterior cortical atrophy: We observed that, while MEN1-KD reduced the expression of MYC at the transcriptional and protein levels in LNCaP and 22Rv1 cells, its expression was maintained in the two MEN1-KD AR-independent PCa cells (Fig. 1f-g and Fig. S1d), suggesting that the difference in cellular activity between AR-dependent and AR-independent PCa cells could be, at least partially, due to MYC expression.