NR3C1 and posterior cortical atrophy: Furthermore, several genetic factors and signaling pathways were shown to bypass AR pathways and thus be involved in AR-independent PCa development, such as P53 [16], RB1 [16], PTEN [17], glucocorticoid receptor (GR) [18], FGF [6] and Stat3/5, as well as the metabolic ACSL pathway [19, 20], whereas the underlying mechanisms remain elusive.