AR and posterior cortical atrophy: Markedly, among these AR-independent CRPCs, some PCas express neither the AR nor markers of neuroendocrine (NE) differentiation (“AR null–NE null”, or double negative PCa, DNPC), and their incidence has risen over the past 2 decades from 5% in 1998–2011 to 23% in 2012–2016 [6].