AR and posterior cortical atrophy: We further evaluated JunD protein expression in MEN1-KD DU145 and PC3 cells, and found that, although MEN1 silencing did not affect the JunD expression at the transcriptional (Fig. 2e and S2b, lower panel) and total protein levels (Fig. 2f and S2c), it triggered the nuclear translocation of JunD in these AR-independent PCa cells (Fig. 2g-h and S2e), indicative of JunD activation [39].