Mitochondrial ROS also activate the NLRP3 inflammasome in multiple pulmonary diseases, consistent with an inflammation model that includes our IL18-pathway and HK1 results, ROS-related proinflammatory responses to lung capillary pressure, and evidence of alveolar epithelial injury/SDB interactions [10, 69, 71–73]. The gene discussed is NLRP3; the disease is lung disorder.