The aim of this study is to investigate whether a clinical LCWGS platform could detect ovarian cancers in patients with pelvic masses based on the abnormal plasma DNA copy number variants (CNVs), and to compare the diagnostic accuracy with traditional screening markers including CA125 and HE4, and the score of risk of ovarian malignancy algorithm (ROMA) [14]. Here, WFDC2 is linked to ovarian carcinoma.