As mentioned above, despite the accumulating evidence on the relationship between NRF2 and SLC7A11 expression, in addition to their effect on radioresistance in various types of cancers, the effect of SLC7A11 and NRF2 on radiosensitivity in ESCC remains to be elucidated. This evidence concerns the gene SLC7A11 and esophageal squamous cell carcinoma.