SLC7A11 and diabetes mellitus: For example, Fan et al. [19] mentioned that the activation of NRF2-Keap1 signaling upregulates SLC7A11 and amplifies the secretion of glutamate, thereby affecting the tumor microenvironment [19], while another study demonstrated that the retinal expression of SLC7A11 is regulated by NRF2 in patients with diabetes [61].