AKT1 and cancer: The further pathway enrichment analysis clarified that modules related to ACs were generally entered in pathways related to viral infection, Immune system, cancer, and inflammation like Human T-cell leukemia virus 1 infection, Toll-like receptor signaling pathway, Pathways in cancer, PI3K-Akt signaling pathway, Chemokine signaling pathway, Cell adhesion molecules (CAMs), NOD-like receptor signaling pathway, Th17 cell differentiation, Th1 and Th2 cell differentiation, JAK-STAT signaling pathway, and MAPK signaling pathway (Additional file 3, Sheet 1).