Moreover, the selected proteins in DiffCoEx_AH were enriched in viral infection, immune system, inflammation, and neurological pathways like Human T-cell leukemia virus 1 infection, PI3K-Akt signaling pathway, Th17 cell differentiation, Th1 and Th2 cell differentiation, MAPK signaling pathway, Apoptosis,, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Sphingolipid signaling pathway, JAK-STAT signaling pathway, Chemokine signaling pathway, Parkinson disease, and Neurotrophin signaling pathway (Additional file 3, Sheet 3). Here, BDNF is linked to viral infectious disease.