Fifteen genes including LTB4R2, HCN4, FZD9, GRIK5, CREB3L4, TACR2, FRMD1, LHB, FGF3, TEAD3, GRIN2D, GNRH2, PRLH, GPR156, and CRHR2 were also determined as potential biomarkers for ATLL. The gene discussed is CRHR2; the disease is adult T-cell leukemia/lymphoma.