METTL16 and melanoma: The results demonstrated that IGF2BP3 mRNA level was upregulated in melanoma tissues as well, while RBM15B and METTL16 was insignificant (Fig. 7A and Additional file 9: S8A), though high expression of RBM15B and METTL16 were associated with poor OS in TCGA database (Additional file 10: Figure S9A–B).