Although gangliosides in general play significant biological functions across many cell types (cell recognition and regulation of membrane-bound signaling proteins such as epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor), the specific role played by GD2 in normal cells is not particularly known but thought to contribute to enhanced tumor cell proliferation, motility, migration, adhesion, invasion, and confers resistance to apoptosis in cancerous cells [26]. Here, EGFR is linked to neoplasm.