Among the latter ones, derivative 43 did not significantly inhibit at 10 μM any of the Ser/Thr kinases tested (PIM-1, mTOR, JNK, CDK5, CHL1), showing selectivity for Src family members over Ser/Thr kinases, including DYRK1A and GSK-3β, which were also implicated in AD pathology. This evidence concerns the gene MAPK8 and Alzheimer disease.