DYRK1A and Alzheimer disease: Likewise, the Aβ peptide has been reported to induce an increment of DYRK1A mRNA levels and to lead to τ phosphorylation at Thr212 under τ overexpression in neuroblastoma cells, suggesting DYRK1A as a key molecule bridging Aβ production and τ phosphorylation in AD (Figure 6) [70].