DYRK1A and Alzheimer disease: Reversal of aberrant τ phosphorylation (Thr212) in DYRK1A-overexpressing mice.Inhibition of DYRK-1A-mediated phosphorylation of APP (IC50 ≈ 80 nM) and PS1 (IC50 ≈ 100 nM).Restoration of the neurological and phenotypic defects in an AD-like Drosophila model [151].