GSK3B and Parkinson disease: Di Martino et al. by applying a hybridization strategy consisting of the introduction of a diethyl fumarate (DEF) fragment at the 4-position of the curcumin scaffold discovered compound 71 (Figure 12) as a brain permeable (Pe = 4.8 × 10−6 cm s−1 in a PAMPA-BBB Assay) dualistic GSK-3β inhibitor/Nrf2 inducer for PD treatment.