EGFR and neoplasm: Moreover, the marked hyper-methylation of epidermal growth factor receptor found by Prokopec et al. in testis samples from ancestrally exposed F3 rats (62% vs. 0% in controls) is also of interest because it occurs within the gene body [67], a mechanism proposed to contribute to transgenerational plasticity in response to environmental stimuli [104] and that is linked to tumor development [105].