TNF and acute kidney injury: In acute kidney injury induced by sepsis in BALB/c mice, TQ administration through gavage reversed CLP-induced increase in serum levels of CRE and BUN and tissue expression of NLRP3, caspase-1, caspase-3, caspase-8, TNF-α, IL-1β, IL-6, and NF-κB, indicating that TQ may have a potential therapeutic benefit against sepsis-induced AKI [76].