Skewed XCI has been demonstrated to play a role in the development of symptomatic phenotypes in female carriers of Duchenne and Becker dystrophinopathies [25], Wiskott–Aldrich Syndrome [26], G6PD [27], and other X-linked disorders. The gene discussed is G6PD; the disease is neuromuscular disease caused by qualitative or quantitative defects of dystrophin.