Finally, Lu et al. conducted a meta-analysis of four GWAS cohorts and revealed a possible association in genes of the psoriasis and CAD: FUT2 encoding an alpha-(1,2) fucosyltransferase, UBE2L3 encoding an ubiquitin-conjugating enzyme involved in cell proliferation and immune function, and SH2B3 encoding the adaptor protein that has a pleiotropic signaling role in regulating lymphocyte differentiation [102]. The gene discussed is FUT2; the disease is psoriasis.