In an animal model of migraine, the injection with the NO-donor isosorbide dinitrate (ISDN), a known migraine trigger, resulted in the increased sensitivity to mechanical stimuli (mechanical allodynia, a common symptom of migraine headache) in animals deficient in both TREK-1 and TREK-2, compared to their wild-type littermates [169]. Here, KCNK2 is linked to migraine disorder.