In the early stage of diabetic retinopathy, Müller cell abnormalities have been observed including increasing expression of glial fibrillar acidic protein (GFAP) [60], swelling of Müller cells [61], and amplifying pro-inflammatory reactions of activated microglia through P2X7 purinergic receptors [62]. The gene discussed is P2RX7; the disease is diabetic retinopathy.