While NKp30a and NKp30b isoforms are associated with pro-inflammatory features, including the production of IFN-γ and TNF-α, NK cells, which predominantly express NKp30c, secrete high levels of IL-10 and present an immunoregulatory phenotype associated with reduced patient survival and response to treatment in many tumor types and auto-immune diseases [189,190,191,192,193,194]. This evidence concerns the gene IFNG and neoplasm.