In the presence of TGF-β, particularly abundant in the tumor microenvironment, NK cells (CD49a−CD49b+) can transdifferentiate into intermediate ILC1 (CD49a+CD49b+), sharing features from both ILC1 and NK cells, and into ILC1 (CD49a+CD49b−) [101,102] (Figure 1). The gene discussed is ITGA1; the disease is neoplasm.