GSTM1 and COVID-19: In this report, we hypothesized that subjecting pulmonary endothelial cells treated with the S1 spike glycoprotein to cell-free Hb may attenuate the SARS-CoV-2 virus pathophysiology, on the basis of the rationale that the S1 protein may bind Hb [30] and the presence of an oxygen carrier may provide therapeutic benefits to COVID-19 patients exhibiting hypoxia [7,31].