It is interesting to note that according to the prevalent acute headache medication, patients who assumed mixtures had a higher serum level of L-PGDS compared to those who assumed NSAIDs or triptans (266.0 ± 44.6 vs. 214.9 ± 53.5 and 209.4 ± 57.5 μg/mL) [28]. This evidence concerns the gene PTGDS and Headache.