CXCL10 and neoplasm: While DOX administration in tumor-free mice did not result in significant changes in the expression of inflammatory markers in the heart, DOX administration significantly abrogated the tumor-induced upregulation of IL-1β (Figure 3B), Mcp-1 (Figure 3E), Cxcl9 (Figure 3G), and Cxcl10 (Figure 3H).