In summary, it is possible that CD8+ TRMs are responsible for the development of flares in eczema, allergic contact dermatitis, and fixed drug reactions, as well as for immunological memory, causing protection against ulcers in systemic sclerosis, protection against actinic keratoses, and protection against rejection in graft-versus-host disease. The gene discussed is CD8A; the disease is Eczematoid dermatitis.