Furthermore, the overall genetic variation in the PLA2 gene (PLA2G4A) in NSAID-induced angioedema was assessed, and rs2049963 was strongly associated with an increased risk for NSAID-induced angioedema [81], suggesting that PLA2 might be more widely involved in the pathogenesis of angioedema than was previously thought. This evidence concerns the gene PLA2G4A and angioedema.