IGHE and angioedema: Bradykinin-induced angioedema (C1-INH deficiency/defect or C1-INH normal), mast-cell-mediated angioedema (IgE-mediated or non-IgE mediated angioedema), and angioedema with an unknown mediator (idiopathic angioedema) are representative major subtypes of angioedema.