TNF and Cachexia: In the last ten years, several molecules have been proposed as biomarkers of cachexia including pro-inflammatory cytokines (e.g., interleukine 6, IL-6 and tumor necrosis factor alpha, TNF-α), hormones (e.g., leptin and ghrelin) and peptides such as C-terminal agrin fragment (CAF) [21,22,23].