Antidepressant drugs and CADs such as the “functional ASM inhibitors” fluoxetine and amitriptyline, can trigger a slow accumulation of SM, cholesterol and other lipids in the lysosome, and induce autophagy (Figure 1C) for instance in hippocampal neurons [151] and furthermore in glioma cells by pimozide and loperamide. This evidence concerns the gene SMPD1 and central nervous system cancer.