Interestingly, sacubitril/valsartan was not superior to valsartan alone in reducing blood pressure, aortic atherosclerosis and abdominal aortic aneurysm in angiotensin II-infused low-density-lipoprotein receptor-deficient mice [32], perhaps because exogenous angiotensin II was the major pathophysiological trigger in this model. This evidence concerns the gene AGT and aortic atherosclerosis.