On the other hand, it is currently not completely defined how celecoxib mediates the activity of NF-κB, but it is possible to assume that it follows the PI3K/AKT/IKK/NF-kB pathway regulation, implicated in the regulation of apoptosis and cell proliferation, as demonstrated in different studies on cancer cell lines [59,60]. The gene discussed is NFKB1; the disease is cancer.