However, in mice with HFD-induced obesity, pharmacological PPARβ/δ activation tackles glucose intolerance and reduces adipocyte size, but not positive UCP1 beige adipocytes were not shown in the sWAT, which may have been because of the enhanced Cidea gene expression, which inhibited the activity of UCP1 by forming a complex [107]. This evidence concerns the gene UCP1 and obesity due to melanocortin 4 receptor deficiency.