CXCL8 and viral infectious disease: A plethora of triggers (endotoxin, ozone, particulates, virus infection, etc.)[164] cause injury to epithelial cells, inducing the release of IL-6, IL-8 and LTB4 to attract neutrophiles and shift immune cells toward Th1 and Th17 helper responses, further increasing IL-8, IL-17, IL-22, IFNγ and TNFα [165].