Similar to the pathways enriched in DMRs from the continuous AF-alb model, the DMRs for the recurrent vs. low model were also enriched in nervous system- (particularly the hypomethylated DMRs; e.g., axon guidance and GABA-R receptor II signalling), inflammatory- (particularly the hypomethylated DMRs; e.g., IL8- and CXCR1-mediated signalling) and adipose- (enriched in both hyper- and hypo-methylated DMRs; e.g., genes targeted by miRNAs in adipocytes, visceral fat deposits and metabolic syndrome, eicosanoid biosynthesis, and regulation of fat cell differentiation) related pathways. This evidence concerns the gene CXCR1 and metabolic syndrome.