Similarly, mice receiving a high-fat diet develop hepatic steatosis and inflammation, which were attenuated by hydroxytyrosol supplementation through PPARα activation, Nrf2 (nuclear factor, erythroid 2 like 2) mediated-antioxidative pathway, and by the downregulation of NF-κB-associated inflammation [240]. This evidence concerns the gene NFE2L2 and Hepatic steatosis.