PPARα deficiency is considered to be a prime factor that either causes or exacerbates fatty acid metabolism impairment, which leads inevitably to the development of numerous metabolic diseases, to name but a few—obesity [204,205], type 2 diabetes mellitus, insulin resistance, dyslipidemia, myocardial infarction, hepatic steatosis without ethanol consumption, termed non-alcoholic fatty liver disease (NAFLD), which includes severe phenotypes such as non-alcoholic steatohepatitis (NASH), liver fibrosis, and hepatocellular carcinoma [206,207,208,209,210]. Here, PPARA is linked to metabolic dysfunction-associated steatotic liver disease.