Tetrahydro-curcumin improves oleic acid-induced hepatic steatosis and ameliorates insulin resistance in HepG2 cells, likely through downregulation of the expression of the lipogenic proteins, SREBP-1c and PPARγ, and the stimulation of lipolysis by upregulating PPARα and CPT-1a, which are involved in fatty acid β-oxidation [235]. Here, PPARA is linked to Insulin resistance.