PPARA and myocardial ischemia: In addition, Ppara ablation exacerbated myocardial ischemia-reperfusion injury in Ppara KO mice models subjected to cardiac ischemia-reperfusion, and interestingly, after the treatment with PEA microparticles (PEA-um®®, 10 mg/Kg), an endogenous PPARα ligand, only Ppara WT mice showed the cardioprotective effect of PEA-um®®, but not in Ppara KO mice.