Likewise, ginsenoside Rb3 micronutrients, derived from ginseng, or nuciferine, found in Nelumbo nucifera leaves, was shown to activate the PPARα pathway by regulating energy metabolism in cardiomyocytes [242], or hepatic steatosis diabetic streptozocin-induced mice fed a high-fat diet [243], while bilobetin, a biflavonoid, modulates PPARα activity by PKA-dependent phosphorylation. Here, PPARA is linked to fatty liver disease.