Markers that were increased among NMO/NMOSD patients include many factors, such as IL-6, IL-17A, G-CSF, High Mobility Group Box 1 Protein (HMGB1), IL-21, IL-8, IL-13, GFAP and osteopontin (OPN) [115]. The gene discussed is CXCL8; the disease is neuromyelitis optica.