5-HA1A-CB2 heteroreceptors were characterized in cortical primary cultures of neurons, and 5-HT1AR-CB2 heteroreceptor complex expression and functionality are significantly enhanced in the brain after cerebral ischemia, especially during the neonatal term, also suggesting that this heteromer is associated with NHIBD pathophysiology [96]. The gene discussed is CNR2; the disease is Cerebral ischemia.