TNF and rheumatoid arthritis: In contrast to the effects on IL-6 and TNF, the treatment with CGS 21680 in high concentrations significantly elevated IL-10 release in both OA and RA synovial cells (OA: 10−7 M p = 0.005; RA: 10−8 M p = 0.022, 10−7 M p = 0.03) (Figure 7).