TNF and rheumatoid arthritis: However, the A2BAR agonist BAY 60-6583 significantly enhanced the TNF levels in both OA ad RA synovial cell cultures (OA: 10−9 M p = 0.007, 10−8 M p < 0.001, 10−10 M compared to 10−9 M p = 0.023, 10−10 M compared to 10−8 M p < 0.001; RA: 10−10 M p = 0.021, 10−9 M p = 0.003, 10−8 M p < 0.001) (Figure 6).