The absolute levels of released cytokine concentrations in untreated control groups were as follows: OA IL-6 205.5 ± 72.9 μg/mL, TNF 348.7 ± 135.3 pg/mL, IL-10 254.0 ± 179.2 pg/mL; RA IL-6 364.5 ± 174.4 μg/mL, TNF 580.2 ± 387.9 pg/mL, IL-10 455.7 ± 235.2 pg/mL. This evidence concerns the gene IL6 and rheumatoid arthritis.