The same treatment conditions also significantly increased TNF release in OA and RA cells compared to the control (OA: 10−6 M p = 0.024, 10−5 M p = 0.001, 10−4 M p = 0.002; RA: 10−6 M p = 0.008, 10−5 M p < 0.001, 10−4 M p < 0.001) (Figure 4A). This evidence concerns the gene TNF and rheumatoid arthritis.