Recently, Kawara and collaborators demonstrated that Spred2 deficiency that represents an inhibitor of the rat sarcoma virus (Ras)/Rapidly Accelerated Fibrosarcoma (Raf)/MEK/ERK pathway involved in cell proliferation and inflammation, increasing the proliferation of lung epithelial cells, ameliorates pulmonary fibrosis induced by bleomycin [59]. The gene discussed is MAP2K7; the disease is pulmonary fibrosis.