ATM and neoplasm: The Cre-loxP and replication-competent avian sarcomaleukosis virus long-terminal repeat with splice acceptor–tumor virus A (RCAS-TVA) technology was used to investigate whether the deficiency of the ataxia telangiectasia mutated (ATM) protein in mouse models of DIPG may allow increasing the sensitivity of the tumor to radiation (Figure 3) [69,70].