CRP and obesity due to melanocortin 4 receptor deficiency: MS is a cluster of cardiovascular risk factors associated with obesity and insulin resistance (IR) and is strongly linked to an increase in the level of systemic inflammation markers such as C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α) and an increase in the free fatty acid (FFA) concentration [2].