However, not unlike BAG3 and HSP7 variants, which exert opposing effects on HCM and DCM progression, mice heterozygous for a null mutation in the Lmna allele do develop DCM over time but more strikingly are partially protected from left ventricular hypertrophy in a pressure-overload model [72]. This evidence concerns the gene BAG3 and familial dilated cardiomyopathy.