Most germline and somatic pathogenic or likely pathogenic variants found in IBC patients in this study correspond to proteins involved in DNA damage repair (BRCA1, BARD1, BRCA2, PALB2, RAD51C, MUTYH, ATM, PMS1, PMS2, MSH2, MSH6), cell cycle control (RB1, TP53, CHEK2) and apoptosis (APC, CASP8). Here, PMS1 is linked to inflammatory breast carcinoma.