Interestingly, transgenic mice without functional TRPM8 channels (TRPM8 knockout mice) showed as high an inflammation level as the control group mice that received CFS and were treated with a vehicle (corn oil), indicating that the impact of suppressing proinflammatory cytokines by 1,8-cineole was mediated by the TRPM8 channel [302]. This evidence concerns the gene TRPM8 and myalgic encephalomeyelitis/chronic fatigue syndrome.