Suppresses: in vivo, suppress inflammatory cytokines, IL-6, IL-1 ß, iNOS, COX-2; suppress dizocilpine induced cognitive impairment; in vitro, suppressed LPS induced NO release, iNOS, COX-2, IL-1 ß, IL-6, TNFα, p65, lkBα, JNK, p38. The gene discussed is MAPK8; the disease is Cognitive impairment.