HOXB8 and neoplasm: In order to identify other mechanisms that might account for the HOXB8 tumor suppressor function in the MEK1ca context, we performed a gene ontology enrichment analysis using the Enrichr analytical tool [34,35,36] for biological processes (GO Biological Processes 2021), for the upregulated genes in the MEK1ca versus pCIG condition among the 759 commonly deregulated genes (FDR1) (between “MEK1ca + HOXB8 versus MEK1ca” and “MEK1ca versus pCIG”), with inverse correlation (519 genes) (Figure 2H, Table S3).