30.4% (704/2316) of the genes (clusters 6–8) behaved oppositely to the genes of clusters 1–5: their expression was downregulated by MEK1ca (MEK1ca versus pCIG) and reversed by HOXB8 (upregulated in “MEK1ca + HOXB8 versus MEK1ca”), and thus might contain new putative tumor suppressors (Figure 3B, Supplementary Table S5). The gene discussed is HOXB8; the disease is neoplasm.