To further the molecular mechanisms involved in the HOXB8 tumor suppressor function, and to identify new oncogenes and tumor suppressors, we performed a clustering analysis of the RNA-Seq data starting with the four experimental conditions and using “k-means” on the list of the 2316 genes deregulated upon MEK1ca expression (MEK1ca versus pCIG) (FDR5) [27] (Figure 3 and Figure S7, Supplementary Tables S4 and S5). Here, HOXB8 is linked to neoplasm.