They also include genes regulated by HOXB8 alone (HOXB8 versus pCIG) (clusters 7–8, Figure 3B), such as LZTS1 (cluster 7, Figure 3B and Figure S9), a leucine zipper tumor suppressor that suppresses colorectal cancer proliferation through inhibition of the AKT pathway [41] and that we have recently found to control neuronal delamination in the trunk neural tube of chicken embryo [12]. Here, AKT1 is linked to colorectal cancer.