IL17A and cancer: For example, the TME harbors various cytokines, chemokines, growth factors, inflammatory mediators, and matrix remodeling enzymes to facilitate crosstalk between TME-constituting cells [78]; this environment can promote polarization of γδ T cells into Th17-or Treg-like cells that produce IL-17 and transforming growth factor (TGF)-β, which favor cancer cell proliferation [79,80].