Bailey et al. recently identified several CILK1 variants in JME patients and also showed that Cilk1 haploinsufficiency in mice produces convulsions and electrographic events (i.e., spikes) associated with JME [11]; notably, only three recording days were sufficient to resolve seizures in Cilk1 mutant mice. Here, CILK1 is linked to juvenile myoclonic epilepsy.