Unexpectedly, this originally simple in vivo Drosophila tumor model, which has been elaborated upon for nearly two decades, has brought insights into tumorigenesis that involves conserved components, associated with malignant cancer progression and bad prognosis in human cancer (loss of cell polarity, aberrant activation of conserved signaling pathways, ROS production, NFκB inflammatory signaling and organ wasting). This evidence concerns the gene NFKB1 and neoplasm.