MBP and experimental autoimmune encephalomyelitis: The mechanisms underlying immune tolerance in MS were studied in animal models for three CNS myelin sheath proteins (proteolipid protein (PLP), myelin oligodendrocyte glycoprotein (MOG), and myelin basic protein (MBP) functioning as target autoantigens in experimental CD4 + T cell-mediated autoimmune encephalomyelitis (Experimental Autoimmune Encephalomyelitis–EAE) [11].