Interestingly, in SM patients, the evidence of high serum levels of sclerostin, a regulator of late osteoblast/pre-osteocyte differentiation associated with osteopenia [115], and 25(OH)D blood values were negatively correlated, and this might suggest that 25(OH)D influences sclerostin levels [115]. The gene discussed is SOST; the disease is Osteopenia.