PFKFB4 and melanoma: The isoform described by Mazano is one of the six isoforms currently available in the NCBI database—so-called isoform B (NM_004567.4), which is considered to be the canonical isoform of PFKFB4. When it comes to the expression of the remaining PFKFB4 isoforms in melanoma, Michenko et al. only demonstrated that an additional PFKFB4 isoform is expressed in the DB-1 melanoma line with 148-bases insert in the 5’-region [16].