In contrast, the plastic caging significantly increased the expression of CD11b/CR3 (p = 0.002) (Figure 12a), C4b (p = 0.002) (Figure 12c), and the mast cell anaphylatoxin complement receptor C5aR1 (p = 0.006) (Figure 12d) in males during acute myocarditis compared to glass caging. The gene discussed is C4B; the disease is myocarditis.