IL1B and myocarditis: Mast cells are key cells that are activated by complement and play a critical role in promoting myocarditis, remodeling, and fibrosis during myocarditis, by releasing enzymes such as α1-antichymotrypsin (serpin A3n) that activate cytokines such as IL-1β and matrix metalloproteinases (MMPs), which drive the remodeling that leads to fibrosis and DCM [22].