In great contrast, lentiPirtLCA at 0.2 × 104 TU dose did not induce any cleavage of SNAP-25 in cultured spinal cord neurons (SCNs) whereas higher dose of virus at 5.4 × 104 TU only produced negligible cleavage of SNAP-25 even at day 5 after infection (Figure 2C,D). The gene discussed is SNAP25; the disease is infection.