WNT1 and familial atrioventricular septal defect: More than 90% of Lrp1m/m (91%: 6% with AVSD, 85% with AVSD and DORV) mice and Wnt1+/cre: Lrp1f/f mutants (92%: 8% with AVSD, 84% with AVSD and DORV) had AVSD.