ICAM1 and Hyperglycemia: Administration of dapagliflozin also suppresses the hyperglycemia-mediated increase in intercellular adhesion molecule-1 (ICAM-1) expression, while empagliflozin decreases the adhesion of human mononuclear leukocytes to human ECs as well as the production of the chemokine C-C motif ligand 2 and 5 by angiotensin II [67,78].