ELF5 is a tumor-suppressor gene for RCC; SLC17A3 is related to the origin of RCC; RALBP1 plays an oncogenic role in RCC; WNK1 promotes renal tumor progression by activating TRPC6-NFAT pathway; APOC1 is significantly correlated with RCC tumor size and histological grade, and CRYAB promotes RCC tumor angiogenesis by increasing vascular survival during tube morphogenesis. The gene discussed is WNK1; the disease is renal cell carcinoma.