The role of this transcription factor in creation of new vessels was demonstrated in Ihida-Stansbury et al.’s study, where authors using Prrx1−/− showed the essential role of PRRX1 for the development and integrity of healthy lung blood vessels [37], whereas other investigators described a correlation between PRRX1 expression and angiogenesis in non-small cell lung cancer (NSCLC), and explored this factor as marker of tumor angiogenesis [38]. Here, PRRX1 is linked to neoplasm.